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The global market for Ion Channel Modulators is projected to decline to US$7.3 billion by 2022, weighed down by patent expirations, generic drug onslaught and lack of promising drugs in the pipeline. Despite data provided by the Human Genome Project use of ion channels as drug targets is limited by their extreme physiological, functional, and structural diversity, and restricted target validation for drug action. Types of ion channel modulators include Ligand-gated ion channels (LGICs), Voltage-gated ion channels (VGICs), aquaporins, and sodium leak channel, among others. The U.S. represents the largest market worldwide. While all other markets are witnessing erosion in growth and revenue, Asia-Pacific ranks as the only pocket of growth in the global market with a CAGR of 1.8% through the analysis period. The growth in the region is sustained by the low cost of ion channel research products as compared to other alternate technologies; tried and tested drug class and the resulting adoption of ion channel based drugs by the medical community; technological advancements in high-throughput screening methodologies; and the still high popularity of calcium channel blocking drugs and sodium channel blockers for cardiovascular diseases including arrhythmias.

DOMAIN EXPERT ENGAGEMENTS

Number of executives repeatedly engaged by snail & email outreach*

POOL + OUTREACH

5068

Interactions with Platform & by Email *

INTERACTIONS

811

Unique # Participated *

PARTICIPANTS

152

Responses Validated *

VALIDATIONS

33

* Platform engagements are dynamic. Stats are published quarterly.


  •  CODE

  •  PAGES

  •  DATE

  •  PRICE

    $

  •  DATA EXHIBITS

    125


TABLE OF CONTENTS


   Pages :    | $

   Study Reliability and Reporting Limitations.....I-1  
   Disclaimers.....I-2
Data Interpretation & Reporting Level.....I-2
  
   Product Definitions and Scope of Study.....I-3  
   Ion Channel Modulators – A Receding Market.....II-11$100
   Current and Future Analysis.....II-2
Aging Population: Creating Need for More Efficient and Safe Drugs.....II-2
1$100
   Table 1: Global Population Worldwide: Percentage Share Breakdown by Age Group for the year 2025 (includes corresponding Graph/Chart).....II-3

Table 2: Global Population of People Aged 65+ Years (In Million) for the Years 2012, 2020 & 2050 (includes corresponding Graph/Chart).....II-3
Competitive Scenario.....II-3
1$350
   Table 3: Leading Ion Channel Modulators Worldwide: 2016 (Percentage Breakdown of Revenues) (includes corresponding Graph/Chart).....II-41$350
   Patent Expiries of Select Ion Channel Modulators.....II-51$100
   Ion Channels – A Peek into Their Types, Functional Use and Diversity.....II-6
Ion Channels – Difficult Drug Targets.....II-6
Currently Available Ion Channel Modulating Drugs in the Market.....II-6
1$100
   Select Ion Channel Modulator Drugs by Mode of Action.....II-73$300
   Ion Channel Modulators by Therapeutic Indication.....II-10
Cardiovascular Diseases/ Hypertension.....II-10
Table 4: Global Annual Medical Cost of CVD in US$ Billion (2010-2030) (includes corresponding Graph/Chart).....II-10
1$350
   Table 5: Fatalities by Heart Conditions - Estimated Percentage Breakdown for Cardiovascular Disease, Ischemic Heart Disease, Stroke, and Others (includes corresponding Graph/Chart).....II-11

Table 6: Fatalities in Low Income Countries by Health Disorder (2015 & 2030): Projected Percentage Breakdown of Number of Deaths for CVD; Cancer; Injury; HIV, TB & Malaria; Malnutrition; and Others (includes corresponding Graph/Chart).....II-11
1$350
   Table 7: Fatalities in Mid Income Countries by Health Disorder (2015 & 2030): Projected Percentage Breakdown of Number of Deaths for CVD; Cancer; Injury; HIV, TB & Malaria; Malnutrition; and Others (includes corresponding Graph/Chart).....II-121$350
   Table 8: Fatalities in High Income Countries by Health Disorder (2015 & 2030): Projected Percentage Breakdown of Number of Deaths for CVD, Cancer, Injury, and Others (includes corresponding Graph/Chart).....II-13
Arrhythmia Treatment.....II-13
Convulsions.....II-13
1$350
   Pain Management.....II-14
Oncology.....II-14
1$100
   Diabetes.....II-15
Ion Channel Modulation of Antiemetics.....II-15
Ion Channel Modulators Find Extensive Use in Neglected Tropical Diseases.....II-15
Other Therapeutic Areas.....II-15
1$100
   Ion Channel Screening Aided by APC.....II-16
Growing Interest in Outsourcing of Ion Channel Services.....II-16
Selectivity against Subtypes – Need of the Hour for Na Channel Blockers.....II-16
1$100
   Select First Gen Sodium Ion Channel Modulators and Indications.....II-171$100
   Sodium Channel Subtypes, Specific Tissues and Indications.....II-18
Strong Potential Na Channel Blockers for Use in Neuropathic Pain.....II-18
New Trial Questions Nifedipine’s Use for Treating Chronic Chilblains.....II-18
1$100
   Ion Channel Modulators: An Introduction.....II-19
Biological Significance of Ion Channels.....II-19
Ion Channel Modulators as an Option for Treating Diseases.....II-19
1$100
   Types of Ion Channels.....II-20
Voltage-Gated Ion Channels.....II-20
1$100
   Extracellular Ligand-gated Ion Channels.....II-212$200
   Intracellular Ligand-gated Ion Channels.....II-231$100
   Xenon Pharmaceuticals Begins Phase I Trials on XEN1101 Potassium Channel
  Opener.....II-24
AstraZeneca Inks Agreement with Aspen for Residual Rights to its Anesthetics
  Portfolio.....II-24
Parion Grants Global Rights for P-321 to Shire.....II-24
Xenon Adds XEN1101 Potassium Channel Modulator to Its Pipeline.....II-24
Alvogen Recalls 24 Lots of Nifedipine.....II-24
Parion Commences Phase II Clinical Trial of P-321.....II-24
1$100
   AstraZeneca Sells Rights of Anesthetics to Aspen.....II-25
AstraZeneca Inks Licensing Deal with CMS.....II-25
Evotec and Asahi Collaborate for Screening of Ion Channel Targets.....II-25
Catalyst Merges with Targacept.....II-25
XRpro Acquires Pfizer’s Ion Channel Biology Platform.....II-25
Vertex and Parion Team Up to Develop ENaC Inhibitors.....II-25
Parion Initiates Enrollment for Phase II Clinical Trial for P-1037 in Cystic
  Fibrosis.....II-25
Biogen Idec Changes Name to Biogen.....II-25
1$100
   Biogen Idec Acquires Convergence Pharmaceuticals.....II-26
Pfizer Wins Court Ruling to Block Generic Versions of Lyrica Upto 2018.....II-26
Forest Labs Discontinues Namenda 5/10 mg Tablets, Launches Namenda XR.....II-26
Forest Files Lawsuit against Namenda Generic Manufacturers.....II-26
Cytocentrics Bioscience Selects Drug Safety Testing Center as its Distributor in
  Japanese Market.....II-26
Zalicus Licenses Its Entire Sodium Channel Modulator Program to AnaBios
  Corporation.....II-26
EPIRUS Merges with Zalicus.....II-26
1$100
   Allergan plc (Ireland).....II-27
AstraZeneca (UK).....II-27
Bayer HealthCare Pharmaceuticals (Germany).....II-27
1$100
   Biogen, Inc. (USA).....II-28
GlaxoSmithKline Plc. (UK).....II-28
1$100
   H. Lundbeck A/S (Denmark).....II-29
Johnson & Johnson (USA).....II-29
Novartis AG (Switzerland).....II-29
1$100
   Parion Sciences, Inc. (USA).....II-30
Pfizer, Inc. (USA).....II-30
1$100
   Sanofi S.A. (France).....II-311$100
   Table 9: World Recent Past, Current and Future Analysis for Ion Channel Modulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....II-321$350
   Table 10: World 8-Year Perspective for Ion Channel Modulators by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for Years 2015, 2017 & 2022 (includes corresponding Graph/Chart).....II-331$350
   A. Market Analysis.....III-1
Current & Future Analysis.....III-1
Strategic Corporate Developments.....III-1
2$150
   Select Key Players.....III-32$150
   B. Market Analytics.....III-5
Table 11: The US Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-5
1$200
   Market Analysis.....III-6
Table 12: Canadian Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-6
1$200
   A. Market Analysis.....III-7
Current & Future Analysis.....III-7
Strategic Corporate Developments.....III-7
1$75
   B. Market Analytics.....III-8
Table 13: Japanese Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-8
1$200
   Market Analysis.....III-9
Table 14: European Recent Past, Current and Future Analysis for Ion Channel Modulators by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-9
1$200
   Table 15: European 8-Year Perspective for Ion Channel Modulators by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets for Years 2015, 2017 & 2022 (includes corresponding Graph/Chart).....III-101$200
   A. Market Analysis.....III-11
Current & Future Analysis.....III-11
Sanofi S.A. – A Key Player.....III-11
1$75
   B. Market Analytics.....III-12
Table 16: French Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-12
1$200
   A. Market Analysis.....III-13
Current & Future Analysis.....III-13
Bayer HealthCare Pharmaceuticals – A Key German Player in the Ion Channel
  Modulator Market.....III-13
1$75
   B. Market Analytics.....III-14
Table 17: German Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-14
1$200
   Market Analysis.....III-15
Table 18: Italian Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-15
1$200
   A. Market Analysis.....III-16
Current & Future Analysis.....III-16
Strategic Corporate Developments.....III-16
Select Key Players.....III-16
2$150
   B. Market Analytics.....III-18
Table 19: The UK Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-18
1$200
   Market Analysis.....III-19
Table 20: Spanish Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-19
1$200
   Market Analysis.....III-20
Table 21: Russian Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-20
1$200
   A. Market Analysis.....III-21
Current & Future Analysis.....III-21
Key Players.....III-21
2$150
   B. Market Analytics.....III-23
Table 22: Rest of Europe Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-23
1$200
   A. Market Analysis.....III-24
Current & Future Analysis.....III-24
Strategic Corporate Development.....III-24
B. Market Analytics.....III-24
Table 23: Asia-Pacific Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-24
1$200
   A. Market Analysis.....III-25
Current & Future Analysis.....III-25
Strategic Corporate Developments.....III-25
1$75
   B. Market Analytics.....III-26
Table 24: Rest of World Recent Past, Current and Future Analysis for Ion Channel Modulators Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-26
1$200
    
 
 


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