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REGENERATIVE MEDICINE - A GLOBAL STRATEGIC BUSINESS REPORT   

Research Abstract

This report analyzes the worldwide markets for Regenerative Medicine in US$ Million. The report provides separate comprehensive analytics for the US, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 52 companies including many key and niche players such as -

AlloSource
Anika Therapeutics, Inc.
Bioventus LLC
DePuy Synthes Companies
Exactech, Inc.

Click here to request a full list of companies covered in the report...

Code: MCP-1241
Price: $4950
Companies: 52
Pages: 303
Date: January 2017
Market Data Tables: 59
 



TABLE OF CONTENTS


  REGENERATIVE MEDICINE (Complete Report) Pages : 303   | $4950

   Study Reliability and Reporting Limitations.....I-1  
   Disclaimers.....I-2
Data Interpretation & Reporting Level.....I-2
  
   Product Definitions and Scope of Study.....I-3  
   Regenerative Medicine: A Preface.....II-11$100
   An Overview of Regenerative Medicine in Bone and Joint Applications.....II-2
Current and Future Analysis.....II-2
1$100
   Developed Markets Dominate, Developing to Drive Growth.....II-31$100
   Regenerative Medicine – Past, Present & Future.....II-41$100
   Another Revolution in the Making?.....II-51$100
   Conventional Chemical Medicine Vs Regenerative Medicine.....II-6
Regenerative Medicine – Bypassing the Ethical Concerns.....II-6
Regenerative Medicine Throws Up Several New Therapies.....II-6
1$100
   Current Global Market for Regenerative Medicine.....II-7
Market Potential.....II-7
1$100
   Therapeutic Companies and Products in Regenerative Medicine – Current Status.....II-81$100
   Key Statistical Data.....II-9
Table 1: Global Regenerative Medicines Market by Category (2016E): Percentage Breakdown for Biomaterials, Stem Cell Therapies and Tissue Engineering (includes corresponding Graph/Chart).....II-9

Table 2: Global Market for Regenerative Medicines by Therapeutic Area (2015): Percentage Breakdown of Number of Therapies Under Clinical Evaluation (includes corresponding Graph/Chart).....II-9

Table 3: Clinical Development Pipeline of Cell and Tissue-Based Therapies by Stage (2015): Percentage Breakdown of Number of Products in Phase I, Phase II and Phase III Trials (includes corresponding Graph/Chart).....II-9
1$350
   List of Major Commercially Available Cell Therapy Products.....II-101$100
   Select Commercial Regenerative Medicine Products in the Global Market.....II-11
Select Regenerative Products in Mid-to-Late-Stage Clinical Development.....II-11
1$100
   Growth Drivers for Regenerative Medicine.....II-12
A Combination of Factors to Drive Regenerative Medicine Market.....II-12
Burgeoning Global Population Offers Significant Growth Opportunities.....II-12
1$100
   Table 4: Top 25 Countries Worldwide in Terms of Population: 2015 & 2016 (includes corresponding Graph/Chart).....II-131$350
   Aging Global Population: Need for New Effective Treatments.....II-14 1$100
   Table 5: Global Population Statistics for the 65+ Age Group (2015) (includes corresponding Graph/Chart).....II-151$350
   Table 6: Comparison of Aging Population by Country (1980, 2015 & 2050): Percentage Share of Population Aged Above-65 Years of the Overall Population for Select Countries (includes corresponding Graph/Chart).....II-161$350
   Table 7: Life Expectancy for Select Countries in Number of Years: 2015E (includes corresponding Graph/Chart).....II-171$350
   Increasing Healthcare Spending in Emerging Markets: Opportunities in Store.....II-18
Table 8: Healthcare Spending as a Percentage of GDP by Region (2016E) (includes corresponding Graph/Chart).....II-18
1$350
   Table 9: Per-Capita Healthcare Expenditure in US$ for Select Countries/Regions (2014) (includes corresponding Graph/Chart).....II-19
Government Support and Increased Private Sector Participation.....II-19
Investment and Funding Landscape.....II-19
1$350
   Major M&A Activity and Strategic Alliances in Regenerative Medicine:
  2011-2016.....II-20
1$100
   Recent Advancements in the Science of Regenerative Medicine.....II-21
Advanced Ceramics Gaining Preeminence in Regenerative Medicine Field.....II-21
1$100
   Table 10: Global Medical Ceramics Market (2015 & 2020): Percentage Breakdown of Value Sales by Application (includes corresponding Graph/Chart).....II-221$350
   3D Organ & Tissue Printing: Still in Early Stages.....II-23
Nanotechnology in Regenerative Medicine.....II-23
Advances in Nanotechnology Assist Regenerative Medicine.....II-23
Issues to be Sorted Out.....II-23
Need for New Scientific and Technological Standards.....II-23
1$100
   Standardized Guidelines.....II-24
Clinical Translation – Collaboration of Multidisciplinary Skills is
  Essential.....II-24
1$100
   The Question of Apt Business Models – The Service and Product Approach.....II-25
Autologous or Service Approach Preferred by European Firms.....II-25
1$100
   Allogenic or Product Approach – Slow to Develop.....II-26
Regenerative Medicine Requires Improved Biomaterials.....II-26
1$100
   Assessment of Worldwide R&D Activities in the Area of Biomaterials.....II-27
Investors Wary of Funding Regenerative Medicine.....II-27
Regenerative Medicine Field Lags Behind Due to Segregated Focus.....II-27
1$100
   Challenges Encountered by Regenerative Medicine.....II-28
Scientific and Technological Challenges.....II-28
1$100
   Barriers in Sharing Intellectual Property Rights.....II-29
Viable Manufacturing Technologies and Skilled Personnel Crucial.....II-29
Strict Regulations Push up Operational Costs.....II-29
1$100
   Challenges Facing Autologous Cell Therapies.....II-301$100
   Bone Regenerative Medicine Presents Need for Advanced Therapies.....II-311$100
   Limitations and Drawbacks for Different Bone Grafts.....II-32
Key Growth Drivers.....II-32
Rising Incidences of Degenerative Intervertebral Disc Diseases.....II-32
1$100
   Table 11: Global Osteoporosis Prevalence by Country/Region (2012 & 2022P): Number of People with Osteoporosis in Millions for US, EU, Japan, China and India (includes corresponding Graph/Chart).....II-33

Table 12: % of Women Affected by Osteoporosis (includes corresponding Graph/Chart).....II-33
Increase in Prevalence of Arthritis and Other Orthopedic Disorders.....II-33
Rise in Revision Orthopedic Surgeries.....II-33
1$350
   Increase in Spinal Fusions in Private Healthcare.....II-34
Bone Grafts Market Maintains Positive Momentum.....II-34
1$100
   Applications of Bone Grafts: A Review.....II-35
Spine Fusion – The Largest Bone Graft Indication.....II-35
1$100
   Dental Bone Grafting – A High Potential Market.....II-36
Table 13: Global Dental Regeneration Market (2013): Percentage Breakdown of Value Sales for Bone Allografts, Membranes, Tissue Regeneration (includes corresponding Graph/Chart).....II-36
What Drives Physicians’ Choice of Bone Grafts?.....II-36
1$350
   Patient Safety Emerges as a Top Priority.....II-37
Bone Graft Substitutes (BGSs) Market: Showing Promising Potential.....II-37
1$100
   Commercially Available Bone Graft Substitutes.....II-382$200
   Growing Clinical Use of Bone Graft Substitutes in Surgical Procedures.....II-40
Synthetic Bone Graft Substitutes to Replace Traditional Autografts and
  Allografts.....II-40
1$100
   Select Synthetic Products in Orthobiologics.....II-41
Orthobiologics Gain Traction in the Bone Grafts Market.....II-41
2$200
   Table 14: Leading Players in the Global Orthobiologics Market (2016E): Percentage Breakdown of Value Sales for AlloSource, DePuy, Integra, Medtronic, MTF, RTI Biologics, Sanofi, Sekagaku, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart).....II-43
Histroical Data for Additional Perspective.....II-43
Table 15: Global Orthobiologics Market (2012): Percentage Breakdown of Value Sales for Allograft & DBM, Blood & Marrow-based Products, Growth Factors, Hemostasis, Synthetic Bone Graft Substitutes and Viscosupplements (includes corresponding Graph/Chart).....II-43
1$350
   Table 16: Global Stem Cell Orthobiologics Market (2012): Percentage Breakdown of Value Sales for Alphatec, NuVasive and Orthofix (includes corresponding Graph/Chart).....II-44
Increasing Visibility of Orthobiological Products to Spur Grafting Options.....II-44
Autograft: Gold Standard for Bone Grafting Procedures.....II-44
1$350
   Allograft: Leading the Race over Autografts.....II-45
Commercially Available Allograft and Xenograft Bone Products.....II-45
1$100
   Allografts Encroach into the Use of Autografts in Surgical Procedures.....II-46
Technological Advancements Drive the Market for Bone Grafts.....II-46
Foot and Extremity Reconstruction – Promising Market for Bone Grafts.....II-46
1$100
   Precision Machined Allograft Gain Surgeon Preference.....II-47
Unmet Clinical Needs to Foster R&D Engine.....II-47
Biological Solutions in Sports Medicine – Beyond Bone Grafting.....II-47
What Ails the Market?.....II-47
Disease Transmission through Bone Grafts – A Major Safety Concern.....II-47
1$100
   Lack of Standards in Bone Graft Substitute Market.....II-48
Reimbursement Issues Continue to Haunt Bone Grafts Market.....II-48
Regional Regulations & Religious Beliefs Hamper Bone Graft Substitutes
  Market.....II-48
1$100
   Synthetic Bone Grafts – Solution for Halal Bone Graft Implantation.....II-49
Bone Glue – A Potential Threat to the Bone Graft Market.....II-49
Alliances with Organ Procurement Organizations: A Shot in the Arm.....II-49
Aging Baby Boomers Render a Decreased Donor Pool.....II-49
1$100
   Limited Availability of Donor Tissues.....II-50
Intense Competition from Alternative Tissue Repair Therapies.....II-50
Substitute Technologies Threaten to Replace Spinal Fusions.....II-50
1$100
   Bone Grafts Termed as Tissues Suffer From Inconsistent Patient Outcomes.....II-51
BMPs and Other Synthetic Growth Factors.....II-51
Bone Morphogenic Proteins (BMPs): Safety Concerns Led to Downfall.....II-51
1$100
   Bone Morphogenic Protein Products in Orthobiology.....II-52
Demineralized Bone Matrices (DBMs) Market: Strong Growth but Tough
  Competition.....II-52
1$100
   Table 17: Global Demineralized Bone Matrix Market (2012): Percentage Breakdown of Value Sales for Altiva, Bacterin, Integra LifeSciences, Medtronic, Synthes/MTF and Others (includes corresponding Graph/Chart).....II-53
Commercially Available Demineralized Bone Matrix Products.....II-53
1$350
   Biomaterials Market – Promising Opportunities for Cost-Effective Products.....II-54
Tissue Engineered Cartilage Market – An Overview.....II-54
Tissue Engineered Cartilages – A Promising Solution for Cartilage Repair.....II-54
1$100
   Stem Cells to Support Tissue Engineering.....II-55
Market Potential of Tissue Engineered Cartilage Products.....II-55
1$100
   Potential Applications of Tissue Engineered Cartilage Products.....II-56
Challenges in Clinical Application of Tissue Engineered Cartilage Products.....II-56
1$100
   Bone Marrow Transplants (BMTs).....II-57
Companies Engaged in CBSC Research for BMTs.....II-57
1$100
   Stem Cell Research – Not Just Another Medical Advancement.....II-58
Sources of Stem Cells.....II-58
1$100
   Stem Cell Based Bone Grafts – Fastest Growing Bone Graft Substitute Segment.....II-591$100
   Commercially Available Cell Therapy Products for Orthopedic Applications.....II-60
Regenerative Stem Cell Products for Spine and Orthopedics in Clinical
  Development.....II-60
Progenitor Cell Therapy to Witness No Holds Barred Growth.....II-60
1$100
   Stem Cell Market on the Verge of Rapid Growth.....II-61
Clinical Development in Adult stem cells Moves Ahead, Lurches in hESCs.....II-61
1$100
   Adult Stem Cell Research Eludes Ethical Dispute.....II-62
Teratomas – No Longer an Impediment to Stem Cell Therapy Development.....II-62
1$100
   Induced Pluripotent – A Potential Competitor to hESCs?.....II-63
Intricate Differences Exist between hESC and iPS Cells.....II-63
1$100
   Use of iPS for Regenerative Medicine.....II-64
Mesenchymal Stem Cells for Regenerative Medicine.....II-64
1$100
   MSC based Models for Orthopedic Repair.....II-65
Delivery of MSCs to Regions Requiring Therapy.....II-65
1$100
   MSCs in the Treatment of Osteoarthritis.....II-66
MSCs in the Treatment of Rheumatoid Arthritis.....II-66
1$100
   Scientific and Technological Challenges in Orthopedic Regenerative Market.....II-67
Bone Regeneration.....II-67
Clinical Approaches in Bone Regeneration and Their Limitations.....II-67
1$100
   Bone Grafts: A Highly Fragmented Market.....II-681$100
   Bone Growth Stimulation Market.....II-69
Table 18: Global Bone Growth Stimulation Market (2016): Percentage Breakdown of Value Sales for Bioventus, DJO, Orthofix and Zimmer Biomet (includes corresponding Graph/Chart).....II-69
Medtronic’s Infuse BMP Lands into Controversy.....II-69
2$350
   Wound Healing – The Second Largest Segment.....II-71
Tissue Engineered Skin Substitutes: Potential Substitutes for Skin grafts.....II-71
1$100
   Commercially Available Tissue Engineered Skin Substitutes.....II-72
Cardiology – Promising Opportunities.....II-72
1$100
   Select Stem Cell Products in the Development for CV Indications.....II-731$100
   Diabetes – Highly Effective Innovative Treatments.....II-74
Regenerative Medicine Products in Development Pipeline for Diabetes.....II-74
Neurodegenerative Diseases – Great Potential.....II-74
1$100
   Body Sculpting/Cosmetics – High Potential.....II-75
Platelet Rich Plasma Treatment Gains Popularity.....II-75
Genetic Disorders.....II-75
Osteoarthritis.....II-75
1$100
   Orthopedic Oncology.....II-76
What’s in Store?.....II-76
Regenerative Medicine to Arrest Ageing?.....II-76
Thriving on an Aging World Population.....II-76
1$100
   Faster Healing Process.....II-77
Regenerative Medicine to Overcome Donor Organs Shortage.....II-77
Possible Scenarios.....II-77
1$100
   Global Regulatory Landscape.....II-78
US.....II-78
FDA Classification of Bone Products.....II-78
Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/Ps).....II-78
1$100
   Good Tissue Practices.....II-79
DBM-based Products in US.....II-79
Synthetic Bone Graft Substitutes.....II-79
1$100
   Tissue Banking Regulation.....II-80
FDA Regulations on Xenograft.....II-80
EU.....II-80
Japan.....II-80
1$100
   Regulatory Norms Governing Embryonic Stem Cell Research.....II-81
Human Embryonic Stem Cell Regulation in Select Countries Worldwide.....II-81
The IP Scenario in the Embryonic Stem Cells Research.....II-81
1$100
   Diversity in Patent Regimes Pose Tremendous Challenges.....II-82
International Divide on Patenting Dents hESC Research.....II-82
1$100
   Orthopedic Industry: An Overview.....II-83
Table 19: Incidence of Fractures by Age Group (2014): Percentage Breakdown of Number of Fractures for Below 45 Years, 45 to 64 Years, and Above 65 Years (includes corresponding Graph/Chart).....II-83
1$350
   Table 20: Global Orthopedic Market by Segment (2015E): Percentage Breakdown of Value Sales for Extremities, Hips, Knees, Orthobiologics, Spine, Trauma and Others (includes corresponding Graph/Chart).....II-84
Medical Devices and Implants for Orthopedics.....II-84
1$350
   Expanding Opportunities in Hip and Knee Market.....II-85
Extremity Reconstruction – A Growing Market.....II-85
Is Consolidation Blowing in the Wind?.....II-85
1$100
   Product Mix of Reconstructive Devices Companies.....II-86
Key Statistics in Global Orthopedics Industry.....II-86
Table 21: Leading Companies in the Global Orthopedic Market (2016E): Percentage Breakdown of Value Sales for DePuy Synthes, Medtronic, Smith & Nephew, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart).....II-86
1$350
   Table 22: Global Orthopedic Market by Application (2016E): Percentage Breakdown of Value Sales for Arthroscopy, Joint Reconstruction, Orthobiologics, Spine, Trauma and Others (includes corresponding Graph/Chart).....II-87

Table 23: Leading Players in the Global Trauma and Extremity Products Market (2016E): Percentage Breakdown of Value Sales for DePuy Synthes, Smith & Nephew, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart).....II-87
Bone Grafts & Joint Revision Arthroplasty.....II-87
1$350
   Table 24: Leading Players in the Global Hip and Knee Replacement Market (2016): Percentage Breakdown of Value Sales for DePuy Synthes, Smith & Nephew, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart).....II-88

Table 25: Leading Players in Worldwide Knee Replacement Market (2016): Percentage Breakdown by Value Sales for DePuy Synthes, Smith & Nephew, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart).....II-88

Table 26: Leading Players in Worldwide Hip Replacement Market (2016): Percentage Breakdown by Value Sales for DePuy Synthes, Smith & Nephew, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart).....II-88
1$350
   Regenerative Medicine – An Introduction.....II-89
Bone Replacements/Grafting: Introduction.....II-89
Bone Grafts: A Peek into their Mechanism of Action.....II-89
1$100
   Types of Bone Grafts.....II-90
Scoring of Osteoconduction, Osteoinduction, and Osteogenesis Properties of Bone
  Grafts by Type.....II-90
Autografts.....II-90
1$100
   Standard Allografts.....II-91
Machined Bone Allografts.....II-91
1$100
   Demineralized Bone Matrix.....II-92
Bone Morphogenetic Proteins (BMPs).....II-92
1$100
   Basic Functions of TGF-Beta.....II-93
Synthetic Bone Grafts.....II-93
Collagen-based Matrices.....II-93
Ceramic: A Material of Choice.....II-93
1$100
   Hydroxyapatite: A Major Calcium Phosphate Based Ceramic.....II-94
Calcium Sulfate.....II-94
Polymer Based Bone Grafts.....II-94
1$100
   Coral: A Valuable Synthetic Graft Material.....II-95
Electrical Bone Growth Stimulators.....II-95
Internal Bone Growth Stimulators.....II-95
External Bone Growth Stimulators.....II-95
1$100
   Cell and Tissue-based Therapies.....II-96
Stem Cells-Based Therapies.....II-96
Bone Tissue Engineering.....II-96
1$100
   Hybrid Materials.....II-97
Osteoinductive Materials.....II-97
1$100
   Immuno-modulatory Biomaterials.....II-98
Advanced Hydrogels.....II-98
Biodegradable Scaffolds.....II-98
1$100
   Orthofix’s New Bone Growth Stimulators Obtain FDA and CE Approvals.....II-99
Anika Therapeutics Obtains CE Approval for ORTHOVISC®-T.....II-99
Zimmer Biomet Rolls Out Bone Allograft PrimaGen.....II-99
Novastep Introduces biofit™ Wedge System.....II-99
Stryker Launches New Hand-held Bone Graft Material Delivery Device.....II-99
Glidewell Unveils New Range of Dental Bone Grafting Products.....II-99
1$100
   AlloSource Launches Two New Demineralized Cortical Fiber Allografts.....II-100
Exactech Launches Acapella® One Cervical Spacer System.....II-100
Anika Therapeutics Rolls Out Viscosupplement CINGAL in the EU.....II-100
NuVasive Launches AttraX® Putty.....II-100
Integra LifeSciences to Launch Omnigraft™ Dermal Regeneration Matrix.....II-100
Anika Therapeutics Secures Approval for Cingal® for Treatment of Osteoarthritic Knee
  Pain.....II-100
Bioventus Launches SIGNAFUSE™ Bioactive Bonegraft Putty.....II-100
1$100
   AlloSource Rolls Out ProChondrix® Cartilage Restoration Matrix.....II-101
MIS Implants Releases 4MATRIX Bone Graft Cement.....II-101
Citagenix Launches PentOS OI™ Putty.....II-101
Medtronic’s Infuse® Bone Graft Receives Approval for New Indications.....II-101
Nordson Introduces Bone Graft Delivery System.....II-101
AmnioLife to Launch New DBM Product Range.....II-101
BioMimetic Secures FDA Approval for AUGMENT® Bone Graft.....II-101
1$100
   TheraCell to Secure Patent for DBF™ Technology.....II-102
Derma Sciences Acquires BioD.....II-102
Histogenics Buys Japanese Developmental and Commercialization Rights to
  NeoCart.....II-102
Integra LifeSciences Inks Deal with AlloSource.....II-102
AlloSource Obtains Patent for ProChondrix® Cartilage Restoration Matrix.....II-102
Exactech Divests Dental Biologics Business to Salvin.....II-102
1$100
   AlloSource Secures Patent for Acellular Human Dermal Matrix.....II-103
AlloSource’s AlloStem® Cellular Bone Allograft Obtains Patent in the US.....II-103
Bioventus Takes Over BioStructures.....II-103
Wright Medical Group Merges with Tornier.....II-103
Ortho RTi to Acquire Technology from Gestion Univalor and Polytechnique
  Montréal.....II-103
Fujifilm Takes Over Cellular Dynamics.....II-103
Anika Therapeutics Files for IDE for Hyalofast.....II-103
1$100
   Zimmer Takes Over ETEX Holdings.....II-104
Aastrom Biosciences Acquires Cell Therapy and Regenerative Medicine Business of
  Sanofi.....II-104
Olympus to Sell the OP-1 Plant.....II-104
Wright Medical Group Divests OrthoRecon Business.....II-104
1$100
   AlloSource (US).....II-105
Anika Therapeutics, Inc. (US).....II-105
1$100
   Bioventus LLC (US).....II-106
DePuy Synthes Companies (US).....II-106
DePuy Synthes Spine, Inc. (US).....II-106
1$100
   Exactech, Inc. (US).....II-107
Integra LifeSciences Holdings Corp. (US).....II-107
1$100
   LifeNet Health, Inc. (US).....II-108
Medtronic, plc (Ireland).....II-108
NovaBone Products LLC (US).....II-108
1$100
   NuVasive, Inc. (US).....II-109
Orthofix International N.V. (Netherlands).....II-109
1$100
   Osiris Therapeutics, Inc. (US).....II-110
Smith & Nephew plc (UK).....II-110
1$100
   Stryker Corporation (US).....II-1111$100
   Wright Medical Technology, Inc. (US).....II-112
Zimmer Biomet Holdings, Inc. (US).....II-112
2$200
   Table 27: World Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - US, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....II-1141$350
   Table 28: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - US, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....II-1151$350
   Table 29: World 14-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).....II-1161$350
   Regenerative Medicine Market by Segment.....II-117
Table 30: World Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications by Segment - Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....II-117
1$350
   Table 31: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Segment - Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....II-1181$350
   Table 32: World 14-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Segment - Percentage Breakdown of Dollar Sales for Bone Replacements, Bone Stimulators, and Tissue Replacements Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).....II-1191$350
   A. Market Analysis.....III-1
Current and Future Analysis.....III-1
US to Retain Leadership Position.....III-1
The Strength of US in Regenerative Medicine – A Glance.....III-1
1$75
   Factors Driving the US Market of Regenerative Medicine.....III-2
Regenerative Medicine in Bone and Joint Applications.....III-2
1$75
   High Potential for Regenerative Medicine in Orthopedics.....III-3
Regenerative Therapy – Best Fit for Joint Problems.....III-3
Bone Grafts Market – An Insight.....III-3
1$75
   Bone Graft Substitutes Market: Opportunities for Growth.....III-4
Aging Population: A Strong Demographic Driver.....III-4
1$75
   Table 33: North American Elderly Population by Age Group (1975-2050) (includes corresponding Graph/Chart).....III-51$200
   Rising Incidence of Degenerative Intervertebral Disc Diseases.....III-6
Back Pain.....III-6
Arthritis.....III-6
1$75
   Table 34: % of Population Diagnosed with Arthritis by Age Group (includes corresponding Graph/Chart).....III-7
Osteoporosis.....III-7
1$200
   Table 35: Osteoporosis and Low Bone Mass Population in the US: 2010 & 2020 (includes corresponding Graph/Chart).....III-8

Table 36: Breakdown of Osteoporotic Fractures by Site in the US (includes corresponding Graph/Chart).....III-8
Rise in Revision Orthopedic Surgeries Boosts Demand.....III-8
Increasing Visibility of Orthobiological Products to Spur Grafting
  Options.....III-8
1$200
   Synthetic Bone Grafts to Fan Growth.....III-9
Spinal Surgery Market: Opportunity for Bone Grafts Market.....III-9
Dental Bone Graft Substitutes Market: An Overview.....III-9
1$75
   Orthopedic Biomaterials Market – An Overview.....III-10
Regulatory Challenges Limit Growth in the US Orthopedic Biomaterials
  Market.....III-10
Orthobiologics Market – Overview.....III-10
1$75
   Adequate Reimbursement: An Impetus for Growth & Profitability.....III-11
Table 37: Payer Mix for Spinal (Cervical) Fusion Procedures in the US (includes corresponding Graph/Chart).....III-11

Table 38: Payer Mix for Spinal (Lumbar) Fusion Procedures in the US (includes corresponding Graph/Chart).....III-11
1$200
   Competitive Scenario.....III-12
Standard Bone Allografts.....III-12
Table 39: US Market for Standard Bone Allografts (2012): Percentage Market Share Breakdown of Leading Tissue Processors (includes corresponding Graph/Chart).....III-12
1$200
   Demineralized Bone Matrix (DBM).....III-13
Table 40: Leading Players in the US DBM Market (2015): Percentage Breakdown of Sales for DePuy Synthes, Interga, Medtronic and Others (includes corresponding Graph/Chart).....III-13
Machined Bone Allografts.....III-13
1$200
   Table 41: US Market for Machined Bone Allografts (2012): Percentage Share Breakdown of Leading Tissue Processors (includes corresponding Graph/Chart).....III-14

Table 42: US Market for Synthetic Bone Graft Substitutes (2012): Percentage Share Breakdown of Value Sales by Company for Biomet, J&J, Stryker, Wright Medical and Others (includes corresponding Graph/Chart).....III-14
1$200
   Stem Cell Market Outlook.....III-15
Millions of American Patients Put their Hope in Stem Cell Research.....III-15
Rapidly Ageing Population Also Spurs Demand for MSC based Therapies.....III-15
1$75
   Regenerative Medicine – Other Areas of Application.....III-16
Regenerative Medicine – Face of Future Revolution in Cardiology.....III-16
Regenerative Medicine in Wound Healing – The Most Widespread Application.....III-16
Regenerative Medicine in Diabetes – A Number of Emerging Applications.....III-16
1$75
   Regenerative Medicine – A Ray of Hope for Neurodegenerative Disease
  Patients.....III-17
Implantable Regenerative Products Take Over Sports Medicine.....III-17
Challenges in the Area of Product Development.....III-17
Process of Integration Continues.....III-17
1$75
   Scientific and Technological Challenges to be Tackled.....III-18
Dominant Patents a Cause of Concern.....III-18
1$75
   Product Approvals/Launches.....III-192$150
   Strategic Corporate Developments.....III-212$150
   Key Players.....III-237$525
   B. Market Analytics.....III-30
Table 43: US Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-30
1$200
   Table 44: US Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....III-311$200
   A. Market Analysis.....III-32
Current and Future Analysis.....III-32
A Peek into Current State of Affairs.....III-32
Regenerative Medicine to Become A Cost Saving Tool..... III-32
1$75
   Japan Takes Steps to Push Forward its RM Science.....III-331$75
   The Discovery of iPS Cells Lends Traction.....III-34
Drug Development – A Major Application for iPS.....III-34
1$75
   Use of iPS for Regenerative Medicine.....III-35
Intractable and Congenital Disease Treatments.....III-35
Research & Development Rife in iPS Cells Space.....III-35
1$75
   General Trends in Regenerative Medicine Industry.....III-36
Research Activity in Regenerative Medicine Field.....III-36
More Companies Eye the Regenerative Medicine Potential.....III-36
1$75
   Competition Heats up Behind Closed Doors.....III-37
Japanese Firms Need to Catch Up with US and European Competitors.....III-37
1$75
   Science Ministry Rolls Out Regenerative Medicine Project.....III-38
Regenerative Medicine Exempted from Ban on Human Cloning.....III-38
Regenerative Medicine - Regulatory Overview in Japan.....III-38
1$75
   The RM Act.....III-39
Japanese Pharma Seeks Regenerative Medicine to Gain Competitive Advantage.....III-39
1$75
   Strategic Corporate Development.....III-40
B. Market Analytics.....III-40
Table 45: Japanese Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-40
1$200
   Table 46: Japanese Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....III-411$200
   A. Market Analysis.....III-42
Current and Future Analysis.....III-42
Great Potential for Regenerative Medicine.....III-42
Challenges Faced by European Regenerative Medicine Industry.....III-42
Orthopedic Biomaterials Market – An Overview.....III-42
1$75
   Synthetic Bone Graft Market Drives the BGS Market.....III-43
Dental Biomaterials Market in Europe: An Insight.....III-43
1$75
   Key Historical Statistical Data for Additional Perspective.....III-44
Table 47: European Bone Graft Substitutes Market by Type (2012): Percentage Share Breakdown of Value Sales for Allograft, DBM and Synthetic (includes corresponding Graph/Chart).....III-44

Table 48: European Market for Standard Bone Allografts by Leading Companies/ Organizations (2012): Percentage Share Breakdown of Value Sales for LifeNet Health, Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical and Others (includes corresponding Graph/Chart).....III-44
1$200
   Table 49: European Market for Machined Bone Allografts by Leading Companies/ Organizations (2012): Percentage Share Breakdown of Value Sales for Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical and Others (includes corresponding Graph/Chart).....III-45

Table 50: European Market for Demineralized Bone Matrix by Leading Companies/ Organizations (2012): Percentage Market Share Breakdown of Value Sales for Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical, Wright Medical Technology and Others (includes corresponding Graph/Chart).....III-45
1$200
   Table 51: European Market for Bone Graft Substitutes by Leading Players (2012): Percentage Share Breakdown of Value Sales for Biomet, Medtronic, Stryker, Wright Medical Technology, Zimmer and Others (includes corresponding Graph/Chart).....III-46
The Need to Embrace Newer Technologies.....III-46
Complex Regulatory Scenario with Multi-tier Governance System.....III-46
1$200
   Need for More Integration.....III-47
Policies Regarding Egg Procurement Weigh Down Research Progress.....III-47
1$75
   Need for Harmonized Clinical Trial Regulation.....III-48
International Alliances – Outsourcing Options with Developing Countries.....III-48
Patenting Issues in hESC Research.....III-48
1$75
   Ageing Population to Drive Demand for MSC based Therapies.....III-49 1$75
   Table 52: Population Breakup by Age Group for Select EU-28 Countries: 2015 (as a Percentage of Total Population) (includes corresponding Graph/Chart).....III-501$200
   Overview of Select Regional Markets.....III-51
Germany.....III-51
United Kingdom.....III-51
Overview.....III-51
Research Councils Announce Ambitious Project to Support Regenerative
  Medicine.....III-51
1$75
   Barriers to Commercialization.....III-521$75
   Product Approvals/Launches.....III-531$75
   Strategic Corporate Developments.....III-54
Key Players.....III-54
2$150
   B. Market Analytics.....III-56
Table 53: European Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-56
1$200
   Table 54: European Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....III-571$200
   A. Market Analysis.....III-58
Current and Future Analysis.....III-58
State of Regenerative Medicine in Asia – An Overview.....III-58
1$75
   Dental Bone Graft Substitutes and Biomaterials Market – An Overview.....III-59
Table 55: Over 65 Years Individuals as % of Total Population in Select Asian Countries: 2015 (includes corresponding Graph/Chart).....III-59
1$200
   Overview of Select Regional Markets.....III-60
China.....III-60
Substantial Government Support.....III-60
A Note on Approved Products.....III-60
Orthopedic Biomaterials Market Poised for Robust Growth.....III-60
1$75
   India.....III-61
High Growth Opportunities.....III-61
Orthopedic Biomaterials and Dental Bone Grafts Market – An Insight.....III-61
1$75
   Rise in Medical Tourism Drives Bone Grafts Market.....III-62
Adult Stem Cells – A Highly Money- Spinning Market.....III-62
Government Takes Steps to Foster Advances in Stem Cell Research.....III-62
1$75
   South Korea.....III-63
Overview.....III-63
Select Products on the Market.....III-63
New Council for RM to Encourage Development.....III-63
1$75
   Malaysia.....III-64
Singapore.....III-64
New Zealand.....III-64
1$75
   Regulatory Developments in the Region.....III-651$75
   B. Market Analytics.....III-66
Table 56: Asia-Pacific Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-66
1$200
   Table 57: Asia-Pacific Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....III-671$200
   A. Market Analysis.....III-68
Current and Future Analysis.....III-68
Overview of Select Regional Markets.....III-68
Canada.....III-68
A Significant Player in the Field of Regenerative Medicine.....III-68
Favorable Growth Prospects in Bone Graft Substitutes Market.....III-68
1$75
   University of Toronto – Spearheading Regenerative Medicine Research.....III-69
BridGE@CCRM – Aims High on RM Commercialization.....III-69
Latin America.....III-69
Argentina.....III-69
1$75
   Brazil.....III-70
Market is Highly Promising but Challenges Remain.....III-70
Overview of Brazilian Orthopedic Devices Market.....III-70
1$75
   Middle East.....III-71
Israel.....III-71
Stem Cell Research in Full Swing.....III-71
1$75
   Product Launch.....III-72
Strategic Corporate Development.....III-72
1$75
   B. Market Analytics.....III-73
Table 58: Rest of World Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).....III-73
1$200
   Table 59: Rest of World Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).....III-741$200
  
Total Companies Profiled: 52 (including Divisions/Subsidiaries - 54)

Region/Country Players

The United States 37 Canada 3 Japan 1 Europe 10 Germany 2 The United Kingdom 2 Rest of Europe 6 Asia-Pacific (Excluding Japan) 1 Middle East 1 Africa 1
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