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G-PROTEIN COUPLED RECEPTORS (GPCRS) - A GLOBAL MARKET REPORT   

Research Abstract

This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in US$ Billion. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for this market. The report profiles 43 companies including 7TM Pharma A/S, Actelion Pharmaceuticals Ltd., Acure Pharma AB, Anchor Therapeutics, Arena Pharmaceuticals, Inc., Addex Pharmaceuticals, Acadia Pharmaceuticals Inc., Cara Therapeutics, Inc., DiscoveRx Corporation, Dimerix Bioscience Pty Ltd., Domain Therapeutics, Euroscreen SA, and Trevena, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

Code : MCP-6269
Price : $4500
Companies : 43
Pages : 286
Date : April 2012
Market Data Tables : 4

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 TABLE OF CONTENTS

  G-PROTEIN COUPLED RECEPTORS (GPCRS) (Complete Report) Pages : 286   | $4500
 
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS  
   Study Reliability and Reporting Limitations.....I-1  
   Disclaimers.....I-2
Data Interpretation & Reporting Level.....I-2
  
   Quantitative Techniques & Analytics.....I-3
Product Definitions and Scope of Study.....I-3
  
II. EXECUTIVE SUMMARY43$3600
  1. INDUSTRY OVERVIEW.....II-15 $395  
   A Quick Primer.....II-1
Why GPCRs Are Important?.....II-1
Untapped Pharmacological Potential of GPCRs Ignites Interest.....II-1
1$100
   Popular Types of GPCRs of Therapeutic Interest Currently Being Studied
  Include:.....II-2
Current Knowledge of GPCR Crystal Structures Just the Tip of the Iceberg.....II-2
1$100
   NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures.....II-3
Orphan GPCRs: A Promising Area for Drug Discovery.....II-3
Developments in Screening Technology for GPCRs.....II-3
1$100
   Cell Membrane Assays for GPCR Quantitative Analysis.....II-4
What’s in for the Pharmaceutical Industry?.....II-4
1$100
   Challenges Aplenty in the GPCR Space.....II-5
Addressing Orphan GPCRs.....II-5
Lack of Structural Information.....II-5
Identification and Classification of Allosteric Sites.....II-5
1$100
  2. G-PROTEIN COUPLED RECEPTORS (GPCR) – A CONCEPTUAL OVERVIEW.....II-616 $1450  
   GPCR: Gateways to Cell.....II-6
Classification of GPCRs.....II-6
1$100
   Table 1: Number of Identified Known and Orphan (Non-Sensory) GPCRs in Human Genome (includes corresponding Graph/Chart).....II-7
Orphan GPCRs and Deorphanization.....II-7
1$300
   List of Select oGPCR-Ligand Pairings Identified By Using Reverse Pharmacology
  Approach (1990-2004).....II-8
Structural Information.....II-8
1$100
   Rhodopsin: A Well Studied GPCR.....II-9
Crystal Structure of Human Beta-2 Adrenergic GPCR.....II-9
Structure of Human A2A Adenosine Receptor.....II-9
1$100
   Significance of GPCR Crystal Structures.....II-10
GPCR Signaling Pathways.....II-10
Physiological Roles Performed by GPCRs.....II-10
Visual Sense.....II-10
Cell-density Sensing.....II-10
Regulation of mood and behavior.....II-10
Smelling Sense.....II-10
Regulating Immune-System Inflammation and Activity.....II-10
1$100
   Automatic Transmission of Nervous System.....II-11
Receptor – Ligand Interaction.....II-11
Types of Ligands.....II-11
Therapeutic Potential of GPCRs.....II-11
1$100
   Major Disease States and Associated Known GPCRs.....II-12
Allosteric Modulators and Implication of Allostery in Drug Discovery.....II-12
Advantages of Allosteric Modulators.....II-12
1$100
   Dimerisation and Role of Dimers in Drug Discovery.....II-13
Oligomerisation and Role of Oligomers in Drug Discovery.....II-13
Functional Selectivity.....II-13
Drug Candidates in GPCR Space.....II-13
1$100
   Select GPCR-Based Drugs Along with Target Receptor and Indication.....II-141$100
   Pipeline GPCR Drug Candidates.....II-15 1$100
   Table 2: GPCR Pipeline by Therapeutic Area: Percentage Breakdown of GPCR Molecules under Development for CNS, Oncology, Cardiovascular Diseases, Metabolic Disorders, GI Diseases and Others (includes corresponding Graph/Chart).....II-16
Select GPCR-Targeting Antibody Drug Candidates in Development.....II-16
1$300
   Select GPCR Antagonists/Agonists in Development for Cancer Treatment.....II-171$100
   Select GCPRs in Development for Non-Cancer Indications.....II-18
Ion Channels.....II-18
Approaches to Drug Discovery in GPCR Space.....II-18
Structure-Based Drug Discovery.....II-18
Ligand-Based Drug Discovery.....II-18
1$100
   Target-Based Drug Discovery.....II-19
GPCR Screening and Targeting Technologies.....II-19
Cell-Based Screening Assays.....II-19
1$100
   Virtual Screening.....II-201$100
   Fragment screening.....II-211$100
  3. RECENT INDUSTRY ACTIVITY.....II-2214 $950  
   Domain Therapeutics Enters into an Agreement with Merck Serono.....II-22
Anchor Therapeutics Makes a Breakthrough in GPCR Collaboration.....II-22
Receptos Collaborates with Lilly GPCR target.....II-22
1$100
   Sanofi-aventis Enters into Licensing Agreement with Metabolex.....II-23
Neurocrine and Boehringer Ingelheim Join Hands to Develop GPR119 Agonists.....II-23
Affitech Enters into Research Collaboration with NTS Plus.....II-23
1$100
   Takeda Cambridge Inks an Agreement to Utilize Dimerix’ GPCR-HIT Platform.....II-24
PerkinElmer Unveils New Detection Kit for Profiling and Screeing GPCRs.....II-24
Omeros Completes Acquisition of GPCR Assay Technology from Patobios.....II-24
1$100
   DiscoveRx Corporation Takes Over KINOMEscan™.....II-25
Roche and ATCC Collaborate on Real-Time Endogenous GPCR Function Research.....II-25
Millipore Launches Luminescent GPCR Reporter Frozen Cells.....II-25
Ascent Therapeutics re-christened as Anchor Therapeutics.....II-25
Affitech Sells Cancer Vaccine Project to Focus on GPCR Research.....II-25
1$100
   Medarex Releases Pre-clinical Data for MDX-1338.....II-26
Compugen Declares Positive Therapeutic Effects of CGEN-25009.....II-26
Addex Releases Clinical Data for ADX10059.....II-26
Arana Receives Patent Approval for PMX53 and Related GPCR Compounds.....II-26
1$100
   Epix Pharmaceuticals Receives Patent Approval for PRX-03140 and Related
  Compounds.....II-27
Odyssey Thera Receives Patent Approval for Fluorescence-Based Assays.....II-27
Cisbio Bioassays Introduces Cellul'erk Assay.....II-27
DiscoveRx Introduces Products and Services to Assays and Reagents Portfolio.....II-27
1$100
   PerkinElmer Introduces Novel Ion Channel and GPCR Cell Lines.....II-28
Millipore Launches New AllostericProfiler™ Service.....II-28
Ligand Pharmaceuticals and Trevena Enter into Agreement.....II-28
ChanTest Takes Over ACS.....II-28
PerkinElmer Enters into Collaboration with Sangmyung University.....II-28
1$100
   Debiopharm Group Inks Exclusive Agreement with MSM Protein Technologies.....II-29
GVK Biosciences and University of Tokyo Sign Agreement.....II-29
MSM Protein Technologies Enters into Alliance with Merck Serono.....II-29
Xenome Enters into Agreement with Axxam.....II-29
1$100
   DiscoveRx and GlaxoSmithKline Inks Global Agreement.....II-30
Sygnature Enters into Contract Chemistry Agreement with Heptares Therapeutics.....II-30
Enzo Life Sciences Enters into Partnership with BioTek Instruments.....II-30
1$100
   Heptares Therapeutics Enters into Agreement with Novartis Option Fund.....II-31
CellAura Enters into Partnership with Cisbio Bioassays.....II-31
Euroscreen and Novartis Ink Research Collaboration Agreement.....II-31
Evotec Enters into Co-marketing Agreement with DiscoveRx.....II-31
Jubilant Biosys Inks Co-marketing Agreement with DiscoveRx.....II-31
1$100
   Faust Pharmaceuticals Changes Name to Domain Therapeutics.....II-32
GSK, MRCT and DiscoveRx Collaborate for Deorphanization of GPCRs.....II-32
DiscoveRx Inks Agreement with BioFocus.....II-32
Actelion's S1P1 Receptor Agonist to Enter into Phase II Clinical Trial.....II-32
1$100
   AnaSpec Introduces Two Isoform Specific Antibodies.....II-33
Millipore Introduces MultiScreen®HTS+ Filter Plates.....II-33
Faust & Takeda Enter into Research Agreement.....II-33
Caliper Life Sciences Collaborates with DiscoveRx.....II-33
Compugen Inks Agreement with Merck Serono.....II-33
1$100
   BioFocus and Amgen Extend Drug Discovery Agreement.....II-34
DiscoveRx Selects Cosmo Bio to Distribute GPCR Profiling Service across Japan.....II-34
Euroscreen Extends Agreement with Cephalon.....II-34
BioFocus DPI Introduces Novel Version of GPCR SARfari.....II-34
1$100
   PerkinElmer Takes Over Euroscreen Products.....II-351$100
  4. FOCUS ON SELECT GLOBAL PLAYERS.....II-366 $495  
   7TM Pharma A/S (Denmark).....II-36
Actelion Pharmaceuticals Ltd. (Switzerland).....II-36
Acure Pharma AB (Sweden).....II-36
Anchor Therapeutics (USA).....II-36
1$100
   Arena Pharmaceuticals, Inc. (US).....II-371$100
   Addex Pharmaceuticals (Switzerland).....II-38
Acadia Pharmaceuticals Inc., (USA).....II-38
1$100
   Cara Therapeutics, Inc. (USA).....II-39
DiscoveRx Corporation (USA).....II-39
Dimerix Bioscience Pty Ltd (Australia).....II-39
1$100
   Domain Therapeutics (France).....II-40
Euroscreen SA (Belgium).....II-40
1$100
   Trevena, Inc. (USA).....II-411$100
  5. GLOBAL MARKET PERSPECTIVE.....II-42   
   Table 3: World Recent Past, Current & Future Market Analysis for G-Protein Coupled Receptors (GPCRs) Targeting Drugs Analyzed with Annual Sales Figures in US$ Billion for Years 2009 through 2017 (includes corresponding Graph/Chart).....II-421$300
   Table 4: World Historic Review for G-Protein Coupled Receptors (GPCRs) Targeting Drugs Analyzed with Annual Sales Figures in US$ Billion for Years 2003 through 2008 (includes corresponding Graph/Chart).....II-431$300
III. COMPETITIVE LANDSCAPE 234$995
  
Total Companies Profiled: 43 

Region/Country                 Players

The United States                 24   
Europe                            15 
     France                        2
     Germany                       1
     The United Kingdom            3
     Italy		           1
     Rest of Europe                8
Asia-Pacific (Excluding Japan)     3
Middle East                        1
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