CHIRAL TECHNOLOGY - A GLOBAL STRATEGIC BUSINESS REPORT   

Research Abstract

This report analyzes the worldwide markets for Chiral Technology in US$ Million, both by Chiral Technology Enabling Products (Intermediates, Analytical, and Others) and by Chiral Technology End Use Markets (Pharmaceuticals, and Agrochemicals). The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a seven-year historic analysis is provided for these markets. The report profiles 38 companies including many key and niche players worldwide such as Albemarle Corporation, BASF AG, Cambrex Corp., Chiral Quest Inc., Dalco ChromTech AB, Daicel Chemical Industries Ltd., Chiral Technologies Worldwide, Chiral Technologies, Inc., Chiral Technologies Europe, DSM Pharmaceutical Products, Johnson Matthey PLC, Regis Technologies Inc., Shasun Chemicals and Drugs Limited, Solvias, Sigma Aldrich Corp, and Suven Life Sciences Ltd. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

Code : MCP-1098
Price : $4500
Companies : 38
Pages : 324
Date : February 2011
Market Data Tables : 45

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 TABLE OF CONTENTS


 
   Study Reliability and Reporting Limitations.......1  
   Disclaimers.......2  
   Data Interpretation & Reporting Level.......3
Quantitative Techniques & Analytics.......3
Product Definitions and Scope of Study.......3
  
   Chiral Technology Enabling Products.......4
Chiral Intermediates.......4
Analytical Products.......4
Other Products.......4
  
   Chiral Technology End-Use Markets.......5
Pharmaceuticals.......5
Agrochemicals.......5
  
   Bright Outlook for the Global Chiral Technology Market.......6
Analysis by Product Segments and End use Markets.......6
Table 1: World Chiral Technology Market by Product Segment (2009): Percentage Share Breakdown by Value Sales for Chiral Intermediates, Chiral Analytical Products, and Others (includes corresponding Graph/Chart).......6
1$350
   Good Tidings for Chiral Technology.......71$100
   Market Drivers.......8
Demand for Chiral-based Therapeutic Drugs Augments Growth.......8
New Legislations Push Chiral Technology Demand.......8
Key Market Trends.......8
Organizations Extend Approaches.......8
1$100
   Companies’ Association with Universities.......9
Trends in Chiral Processes.......9
Increasing Reliance on Generic Approaches.......9
Predominant Use of Polysaccharides Derivatives as CSPs.......9
Automation: Introduction of Instruments Supporting Chiral Processes, a Growing
  Trend.......9
1$100
   An Insight into Chiral Technology.......10
Techniques Used for Achieving Single-Isomers.......10
1$100
   Table 2: World Chiral Technology Market (2002 & 2010): Percentage Breakdown of Revenues by Techniques- Traditional Methods, Asymmetric Methods, and Biological Methods (includes corresponding Graph/Chart).......11
Importance and Advancements.......11
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   Definitions.......13
Chiral Technology Enabling Products.......13
Chiral Intermediates.......13
Analytical Products.......13
Other Products.......13
1$100
   Chiral Technology End-Use Markets.......14
Pharmaceuticals.......14
Agrochemicals.......14
Description.......14
1$100
   Functioning of Chiral Molecules.......15
Chiral Preparation Process.......15
Traditional Methods.......15
1$100
   Biological Methods.......16
Asymmetric Methods.......16
1$100
   Chiral Separation.......17
Factors Influencing the Efficacy of Chiral Separations.......17
Recent Approaches in Chiral Separations.......17
Extensive Use of Supercritical Fluid Chromatography (SFC).......17
1$100
   Chromatography – The Widely Used Method for Separation.......18
How it Works?.......18
1$100
   Chiral Mobile Phase Additive (CMPA).......19
Chiral Stationary Phase (CSP).......19
1$100
   List of Newly Introduced Generic Versions of Derivatized Amylose and Cellulose
  Phases.......20
Challenges and Novel Concepts in the Development of Chiral Stationary
  Phases.......20
Novel Concepts.......20
1$100
   Chiral Recognition.......21
Protein Chiral Stationary Phases.......21
Carbohydrate Columns.......21
Pirkle Columns.......21
1$100
   Crystallization.......22
Solvent Extraction.......22
1$100
   Kinetic Resolution.......23
Capillary Electrophoresis.......23
Receptor Based Resolution.......23
1$100
   Miscellaneous Separative Techniques.......24
Chiral Synthesis.......24
1$100
   In-House Creation & Development.......25
Acquisition of Technology.......25
1$100
   “Economics” of Chiral Technology.......261$100
   Chiral Analysis: A Primer.......27
Chiral Analysis Products.......27
Chiral Analytical Chromatography.......27
Chiral Liquid Chromatography.......27
1$100
   Supercritical Fluid Chromatography - Substitute to LC for Enantiomer
  Separations.......28
Chiral Gas Chromatography.......28
Chiral Simulated Moving Bed Chromatography.......28
Partition Chromatography.......28
1$100
   Adsorption Chromatography.......29
Computer Assisted Resolution.......29
Chiral Polarimetry.......29
1$100
   Other Chiral Analytical Techniques.......30
Calorimetry.......30
Differential Scanning Calorimetry (DSC).......30
Enzymatic Assay.......30
Immunoassay.......30
1$100
   Isotope Dilution.......31
Nuclear Magnetic Resonance (NMR).......31
X-Ray Crystallography.......31
1$100
   Pharmaceuticals – The Largest Market.......32
Changing Face of the Pharmaceutical Industry: A Review.......32
Analysis of Chiral Drugs.......32
1$100
   Select Companies Involved in Chiral Technology Market.......33 1$100
   Table 3: Single-Enantiomer Drugs Market Worldwide (2006- A Recent past Perspective): Sales of Select Leading Brands (In US$ Billion) (includes corresponding Graph/Chart).......34
Drugs Built on Chiral Technology.......34
Analgesics.......34
1$350
   Anesthetics.......35
Anti-Infective Products.......35
Cardiovascular System (CVS) Products.......35
Angiotensin-Converting Enzyme (ACE) Inhibitors.......35
Beta-Blockers.......35
1$100
   Calcium Channel Blockers.......36
Diuretics.......36
Vasodilators.......36
Central Nervous System (CNS) Agents.......36
Anticonvulsants.......36
Sedatives and Tranquilizers.......36
Stimulants and Antidepressants.......36
1$100
   Oncogenic (Cancer-Treatment) Products.......37
Biochemicals.......37
Oligonucleotides.......37
1$100
   Oxyacids.......38
Amino Acids.......38
1$100
   Sugars and Other Oligosaccharides.......39
Vitamins.......39
1$100
   Peptides.......401$100
   Pesticides – A Thriving Market.......41
Herbicides.......41
Insecticides.......41
1$100
   Fungicides.......42
Other Products.......42
Liquid Crystals.......42
1$100
   Flavor and Aroma Chemicals.......431$100
   Organic Chemical Isomerism Types.......44
Structural Isomerism.......44
Chain Isomerism.......44
Position Isomerism.......44
Functional Group Isomerism.......44
Stereoisomerism.......44
1$100
   Dynamic Isomerism (Tautomerism).......45
Patents.......45
1$100
   Regulatory & Environmental Issues- A Review.......461$100
   Phenomenex Introduces Chiral Screening Service.......47
AminoLogics Develops a Novel Chiral Converting Molecule for Amino Acids.......47
Chiral Technologies Worldwide to Display 3-ěm and Protein-based Reversed Phase
  Columns.......47
1$100
   Chiral Technologies Introduces 3µm Chiral Stationary Phases for Rapid Analysis.......48
Chiral Technologies Introduces 5µm Versions of Polysaccharide-Based Chiral
  Stationary.......48
Semba Launches Semba Octave™ Chromatography System.......48
1$100
   Modular SFC to Launch Chiral Centrifugal Fraction Collector and Sample Concentration
  System.......49
Chiral Technologies Introduces New Versions of Immobilized IC and IA Chiral
  Phases.......49
1$100
   PDR-Chiral Develops AutoMDS for Automated Screening of Chiral and Achiral
  Substances.......50
Waters Introduces New Products Under the UPLC Line.......50
1$100
   Sigma-Aldrich/Supelco Introduces Astec CHIROBIOTIC™ Chiral HPLC Columns.......51
Sigma-Aldrich/Supelco Introduces Astec CYCLOBOND™ Chiral HPLC Columns.......51
Chiral Technologies Introduces CHIRALPAK® IC Columns Under Polysaccharide Product
  Range.......51
1$100
   Degussa Develops Novel Processes to Synthesize (S) CAP.......52
Regis Technologies, Inc. Launches RegisPack Chiral Columns.......52
Sigma-Aldrich Introduces ChiroSolv™ Kits.......52
1$100
   Sigma-Aldrich Launches Ascentis Express HPLC Columns.......53
Evolved Nanomaterial Releases Revolutionary Analytical Chiral Column.......53
BASF Develops Novel Process to Produce Chiral Intermediates.......53
Sepiatech Launches Sepmatix Parallel HPLC system.......53
1$100
   MACHEREY-NAGEL Launches Novel NUCLEOCEL CSP Columns.......54
Eksigent to Launch Express™ HPLC System.......54
1$100
   Chiral Quest Launches C3 TunePhos.......551$100
   WR Grace Takes Over Synthetech.......56
Daicel Chiral to Start a New Branch in Beijing.......56
Saltigo Concludes Process Development Agreement with Reuter Chemische.......56
Chiral Technologies Europe Inks Global Licensing Agreement with University of
  Vienna.......56
1$100
   Shasun Announces Change of Name.......57
CT Worldwide Announces the Launch of a Novel Microsite.......57
Chiral Technologies Partners with Vanderbilt University’s Program in Drug
  Discovery.......57
DSM Renews Co-Operation Agreement with Fudan University.......57
1$100
   Chiral Technologies Europe Inks Distribution Agreement with HICHROM.......58
Dow Sells Dowpharma Small Molecules Business.......58
1$100
   Daicel Chemical Establishes New Subsidiary in China.......59
Chiral Technologies Europe Takes Over ChromTech.......59
Cambrex to Buy ProSyntest AS.......59
1$100
   Johnson Matthey and X-Zyme Sign Licensing Agreement.......60
Chiral Quest Starts a New Production Facility.......60
Chiral Quest Completes Reverse Merger with Surg II.......60
DSM and IEP Extend Partnership.......60
Shasun Chemicals Acquires Rhodia Pharma Solutions.......60
1$100
   Sigma-Aldrich Corp Acquires Astec.......61
Solvias Receives License for MeOBIPHEP Catalyst Technology.......61
Codexis Acquires Juelich Fine Chemicals.......61
ChiroBlock Exits from Chiral Compounds Business.......61
Chiral Quest Opens New Facility in China.......61
Chiral Quest to Supply C3 TunePhos to Phoenix Chemicals.......61
1$100
   Lonza and Codexis Sign Agreement for Biocatalysis Process.......62
DSM Signs Licensing Agreement with Chiral Quest.......62
Chiral Quest Signs Distribution Agreement with Aldrich Chemical.......62
BASF and Solvias to Collaborate on Chiral Molecule Development.......62
Chiral Quest and Avantium Enter into Partnership.......62
1$100
   Albemarle Corporation (USA).......63
BASF SE (Germany).......63
Cambrex Corp. (USA).......63
1$100
   Chiral Quest Inc. (US).......64
Dalco ChromTech AB (Sweden).......64
Daicel Chemical Industries Ltd. (Japan).......64
1$100
   Chiral Technologies Worldwide.......65
Chiral Technologies, Inc. (USA).......65
Chiral Technologies Europe (France).......65
DSM Pharmaceutical Products (The Netherlands).......65
1$100
   Johnson Matthey PLC (UK).......66
Regis Technologies, Inc. (USA).......66
Shasun Pharmaceuticals Limited (India).......66
1$100
   Solvias (Switzerland).......67
Sigma Aldrich Corp. (USA).......67
Suven Life Sciences Ltd. (USA).......67
2$200
   Table 4: World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......691$350
   Table 5: World Historic Review for Chiral Technology Enabling Products by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......701$350
   Table 6: World 11-Year Perspective for Chiral Technology Enabling Products by Geographic Region – Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......711$350
   Table 7: World Recent Past, Current & Future Analysis for Chiral Intermediates by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......721$350
   Table 8: World Historic Review for Chiral Intermediates by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......731$350
   Table 9: World 11-Year Perspective for Chiral Intermediates by Geographic Region – Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......741$350
   Table 10: World Recent Past, Current & Future Analysis for Chiral Analytical Products by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......751$350
   Table 11: World Historic Review for Chiral Analytical Products by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......761$350
   Table 12: World 11-Year Perspective for Chiral Analytical Products by Geographic Region – Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......771$350
   Table 13: World Recent Past, Current & Future Analysis for Other Chiral Technology Enabling Products by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......781$350
   Table 14: World Historic Review for Other Chiral Technology Enabling Products by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......791$350
   Table 15: World 11-Year Perspective for Other Chiral Technology Enabling Products by Geographic Region – Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......801$350
   Table 16: World Recent Past, Current & Future Analysis for Chiral Technology in Pharmaceuticals by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......811$350
   Table 17: World Historic Review for Chiral Technology in Pharmaceuticals by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......821$350
   Table 18: World 11-Year Perspective for Chiral Technology in Pharmaceuticals by Geographic Region – Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......831$350
   Table 19: World Recent Past, Current & Future Analysis for Chiral Technology in Agrochemicals by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......841$350
   Table 20: World Historic Review for Chiral Technology in Agrochemicals by Geographic Region – US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......851$350
   Table 21: World 11-Year Perspective for Chiral Technology in Agrochemicals by Geographic Region – Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......861$350
   A. Market Analysis.......87
Overview.......87
1$100
   B. Market Analytics.......88
Table 22: US Recent Past, Current and Future Analysis for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......88
1$350
   Table 23: US Historic Review for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......891$350
   Table 24: US 11-Year Perspective for Chiral Technology Enabling Products by Product Segment – Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......901$350
   Table 25: US Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......911$350
   Table 26: US Historic Review for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......92

Table 27: US 11-Year Perspective for Chiral Technology by End-Use Segment – Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2005, 2010 & 2015.......92
1$350
   A. Market Analysis.......93
Outlook.......93
B. Market Analytics.......93
Table 28: Japanese Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......93
1$350
   Table 29: Japanese Historic Review for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......941$350
   Table 30: Japanese 11-Year Perspective for Chiral Technology Enabling Products by Product Segment – Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2005, 2005 & 2015 (includes corresponding Graph/Chart).......951$350
   Table 31: Japanese Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......961$350
   Table 32: Japanese Historic Review for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart).......97

Table 33: Japanese 11-Year Perspective for Chiral Technology by End-Use Segment – Percentage Breakdown of Value Sales for Pharmaceuticals and Agrochemicals Markets for Years 2005, 2005 & 2015.......97
1$350
   A. Market Analysis.......98
Overview.......98
1$100
   B. Market Analytics.......99
Table 34: European Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......99
1$350
   Table 35: European Historic Review for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......1001$350
   Table 36: European 11-Year Perspective for Chiral Technology Enabling Products by Product Segment – Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......1011$350
   Table 37: European Recent Past, Current and Future Analysis for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......1021$350
   Table 38: European Historic Review for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......103

Table 39: European 11-Year Perspective for Chiral Technology by End-Use Segment – Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2005, 2010 & 2015.......103
1$350
   A. Market Analysis.......104
Outlook.......104
India.......104
Chiral Drugs in the Indian Market.......104
China-A Hub for Pharmaceutical Manufacturing.......104
1$100
   B. Market Analytics.......105
Table 40: Rest of World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......105
1$350
   Table 41: Rest of World Historic Review for Chiral Technology Enabling Products by Product Segment – Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......1061$350
   Table 42: Rest of World 11-Year Perspective for Chiral Technology Enabling Products by Product Segment – Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).......1071$350
   Table 43: Rest of World Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......1081$350
   Table 44: Rest of World Historic Review for Chiral Technology by End-Use Segment – Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......109

Table 45: Rest of World 11-Year Perspective for Chiral Technology by End-Use Segment – Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2005, 2010 & 2015.......109
1$350
  
Total Companies Profiled: 38 (including Divisions/Subsidiaries - 48)

Region/Country Players

The United States 29 Canada 1 Japan 2 Europe 12 France 4 Germany 1 The United Kingdom 2 Italy 1 Rest of Europe 4 Asia-Pacific (Excluding Japan) 4
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